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Outcomes the in-patient had deterioration of sight when you look at the remaining attention with subclinical optic neuropathy within the right eye, with medical features resembling ischemic optic neuropathy. Additionally, he developed a modification of state of mind with weakness of extremities. After the cessation of tacrolimus, the aesthetic reduction remained however the various other neurologic symptoms resolved. Conclusion Tacrolimus may be involving optic neuropathy and PRES