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Sedentary behaviour is a major risk of mortality. However, data are contradictory regarding the effects of active commuting on mortality. To perform a systematic review and meta-analysis on the effects of active commuting on mortality. The PubMed, Cochrane Library, Embase, and Science Direct databases were searched for studies reporting mortality data and active commuting (walking or cycling) to or from work. We computed meta-analysis stratified on type of mortality, type of commuting, and level of commuting, each with two models (based