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Additional high-quality research in these areas is needed to further identity patients who may benefit most from TXA. Non-infectious inflammation has been proposed as a major contributor to epidural-related maternal fever. We hypothesized that maternal serum C-reactive protein (CRP) and white blood cell (WBC) count at hospital admission predict intrapartum maternal fever. A retrospective case-control study of low-risk women admitted for vaginal deliveries at a tertiary hospital in 2019. Women with a singleton pregnancy at term and a ce