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Few studies have evaluated the effects of ambient air pollution exposure on lung function, especially in areas with high air pollution levels. To investigate the associations of annual concentrations of particulate matter with diameters2.5μm (PM ) and nitrogen dioxide (NO ) with adult lung function in Shanghai, China. We included 5276 permanent residents aged≥20years. Annual residential exposure to PM and NO was estimated by validated satellite-based and land use regression models, respectively. The effects of PM and NO on lung function were estimated s