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© 2020 American Association of Neuropathologists, Inc.Isoprenoids constitute the largest class of plant natural products and have diverse biological functions including in plant growth and development. In potato (Solanum tuberosum), the regulatory mechanism underlying the biosynthesis of isoprenoids through the mevalonate pathway is unclear. We assessed the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) homologues in potato development and in the metabolic regulation of isoprenoid biosynthesis by generating transgenic line