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In a PLY and A549 cell co-incubation system, the addition of ESG triggered considerable defense against PLY-mediated mobile damage. Moreover, S. pneumoniae-infected mice revealed reduced death, and eased tissue harm and inflammatory reactions after therapy with ESG. Our results indicate that ESG is a potential applicant treatment for S. pneumoniae disease that targets PLY. This finding partly elucidates the apparatus regarding the Chinese org