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In this article, in celebration of the 50th anniversary of the South African Medical Research Council (SAMRC), the authors explain the SAMRC's very first foray into this "" new world "" of financing through a SIB to enhance the health and standard of living of teenage women and women (AGYW). The AGYW SIB is within its preparatory stage and it is planned for implementation in 2020. The authors explain the method, including monetary flows and the means of customising the SI