https://www.selleckchem.com/pr....oducts/gsk2830371.ht
The effects of IGF-1 in this process may depend on its function in regulating the PI3K/Akt signaling pathway.NEW NOTEWORTHY IGF-1 expression was downregulated by sevoflurane anesthesia in rats and could be rescued by intravenous IGF-1 injection, which alleviated sevoflurane-caused cognitive injuries and enhanced inflammatory responses in aged rats. Intravenous injection of IGF-1 rescued sevoflurane-depressed Akt phosphorylation in aged rats.Unilateral-onset spike-wave discharges (SWDs) following fluid percussion injury (FPI) in
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