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These results suggest that selective S1P1R modulation has the ability to provide neuroprotection in reaction to MPTP neurotoxicity. Concentrating on S1P1R in PD treatment may express a prominent candidate for remedy for this neurodegenerative problems. Copyright © 2020 Pépin, Jalinier, Lemieux, Massicotte and Cyr.Introduction Acoustic group treatment (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters