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The semantic gap can be bridged by the learned feature-label correlation. Finally, extensive experimental results on several benchmarks under four domains are presented to show the effectiveness of the proposed framework.Quantitative assessment of retinal layer thickness in spectral domain-optical coherence tomography (SD-OCT) images is vital for clinicians to determine the degree of ophthalmic lesions. However, due to the complex retinal tissues, high-level speckle noises and low intensity constraint, how to accurately re