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P in real seafood samples, exhibiting many advantages. It could not only specifically enrich and rapidly separate the V.P in complex samples but also largely amplify the signal. Moreover, using compact SPE with a detection time of maximum 20 min as the measurement platform allows rapid on-site assays. Thus, the proposed method is a feasible strategy for screening V.P in seafood.Carcinoembryonic antigen (CEA) is a well-known cancer biomarker for the detection of several malignancies. The development of ultrasensitive CEA diagnostic tools i