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High emitted dose and total lung dose showed promising aerosol performance of the produced particles for use as a drug loading platform for respiratory drug delivery. Two types of longer-chain lipid particles with higher main phase transition temperatures, 1,2-diarachidoyl-sn-glycero-3-phosphocholine (DAPC) and 1,2-dibehenoyl-sn-glycero-3-phosphocholine (220 PC), yielded similar rugose morphologies when spray dried at correspondingly higher processing temperatures. Rugose lipid particles produced via spray drying from an aqueous suspensio