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modulation of anatomical networks.This study aimed at estimating parameters representing between-farm transmission of Salmonid Rickettsial Septicaemia (SRS) in Chile, and developing and validating simulation models to predict weekly spread of SRS between farms in Los Lagos (Region 1, using InterSpread Plus. The model parameters were estimated by analyses of the historical SRS outbreak data. The models incorporated time and distance-dependent transmission kernels, representing the probabilities of waterborne spread of SRS between farms