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Areas of difficulties included the morphological boundaries of HG-BCL, not otherwise specified, cases with MYC and BCL2 or BCL6 translocations and TdT expression, which were categorized as B-lymphoblastic lymphoma/leukemia if most cells showed TdT positivity, and the clinico-pathologic overlap between intravascular large B-cell lymphoma, DLBCL CD5+ and DLBCL with primary presentation in BM, spleen and liver. This review summarizes our understanding of the main aggressive B-cell lymphoma categories with common primary BM presentation an
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