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Copyright © 2020 Ramírez-Uclés and Ramírez-Uclés.The current research reports both latent profile (person-oriented) and item response theory (IRT) analyses of the School Burnout Inventory (SBI) in United States undergraduate samples. Study 1 (n = 1,007) comprises a latent profile analysis (LPA) that identified four mutually exclusive subgroups based on patterns of school burnout responses. Covariate analyses of grade point average and negative affect suggested that school burnout profiles function similarly to variable-oriented approaches.