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In addition, the microcystic elongated and fragmented (MELF) pattern and tumor budding had been compared with respect for their prospective as markers for epithelial-mesenchymal change (EMT). Tumor budding was found in n = 67 (26.3%) tumors, with an extremely reasonable mean of 0.7 buds per ×20 HE area. Tumefaction budding was notably involving level of intrusion, nodal condition, lymphatic invasion (each p less then 0.001), grading (p = 0.004), and vascu prognostic potential in the
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