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Pneumonia due to (PA) is associated with high mortality and requires antipseudomonal treatment. Since PA can colonize the respiratory tract, the diagnosis of pathogenic PA involvement is challenging. To determine the prevalence of definitive and indeterminate PA infection in community-acquired pneumonia, to describe the clinical and microbiological profiles and to estimate the burden of unnecessary antipseudomonal drug prescriptions. We prospectively enrolled 2,701 patients with community-acquired pneumonia. Using stringent criteria f