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An overall total of 378 DEGs were found. GO and KEGG analysis unveiled that the DEGs had been primarily enriched into the cell pattern. There have been positive correlations among CDK1, polo-like kinase 1, shugoshin2 and anillin actin-binding protein. Additionally, the expression levels of four core genetics were associated with the HCC occurrence, pathological stages, and survivorship bend. The medical HCC specimens verified the higher expression degree of core genetics by real-time RT-PCR.