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The development of bone tissue engineering indicates some new paths for bone defect repair. Mild photothermal therapy (PTT) is flourishing as an exciting potential method for bone regeneration. Polydopamine nanoparticles exhibit good absorption at infrared wavelengths and can be used as a viable option for the application of mild PTT to bone defects. Herein, a gelatin-methacryloyl/poly(methyl methacrylate)/polydopamine (GelMA/PMMA/PDA) hydrogel was formulated and assessed in terms of mechanical and biological features. We observed that