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We also identified 2 upregulated genes, namely , and a downregulated gene as hub genes for nut allergy. Further pathway analysis showed enrichment of type 1 interferon signalling in nut allergy. Our findings suggest that upregulation of type 1 interferon signalling and neutrophil responses and downregulation of CD4 T-cells and Tregs are features of the pathogenesis of nut allergy. Our findings suggest that upregulation of type 1 interferon signalling and neutrophil responses and downregulation of CD4+ T-cells and Tregs are features of th