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Does ADHD Medication Work? When someone receives a prescription for ADHD medication, they often be concerned about whether the medication will work and how long it will last. Here are some easy answers. Stimulants alter brain chemicals that transmit messages about activity and attention. They include dopamine and norepinephrine. They are considered to be the first line treatment option for adults suffering from ADHD. 1. Stimulants Stimulants are the most commonly prescribed drugs to tr