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Finding the Best Medication For ADHD Stimulants are among the most frequently prescribed drugs for ADHD. Amphetamines and methylphenidates are among the most frequently prescribed stimulants. Short-acting stimulants are effective within less than an hour and need to be taken several times per day. Long-acting stimulants last up to 16 hours, and are usually taken just once per day. Your doctor might prescribe antidepressants, or other medications "off-label" to treat ADHD sympto