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The inflammation causes a typical clinical phenotype including orogenital ulcerations, uveitis and skin lesions. Treatment is aimed at the aberrations found in the innate (neutrophils and γδ-T cells) and adaptive immune system (TNF-α, INF-γ, IL-1), directed at organ involvement and individualized based on patient characteristics. We presented an extensive review into the pathogenesis and treatment options of BD. We presented an extensive review into the pathogenesis and treatment options of BD. To evaluate the relation between whole