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a higher failure rate and a considerably lower efficiency. Fluid management is important in ensuring haemodynamic stability in critically ill patients, but can easily lead to fluid overload (FO). However, the optimal fluid balance plot or range for critically ill patients is unknown. This study aimed to explore the dose-response relationship between FO and in-hospital mortality in critically ill patients. Multicentre, prospective, observational study. Eighteen intensive care units (ICUs) of 16 tertiary hospitals in China. Critically ill
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