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Negative associations between changes in cognition (executive function [LPFC O2Hb r = -0.45, P = .049; LPFC tHb r = -0.49, P = .030] and fluid composite score [RPFC Hbdiff r = -0.47, P = .038; LPFC Hbdiff r = -0.45, P = .048]) and PFC changes were detected. The change in cardiorespiratory fitness was positively associated with the change in working memory score (r = 0.55, P = .016). Cardiovascular disease patients enrolled in CR showed significant improvements in multiple cognitive domains along with increased cortical activation. The neg