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How Does ADHD Medication Work? Stimulants are the initial line of treatment for ADHD. They aid in regulating the levels of two brain chemical substances (neurotransmitters) which transmit messages between neurons to improve attention and decrease hyperactivity. 20% of people are not sensitive to stimulants like amphetamine or methylphenidate. This may be due to their body chemistry or other medications they are taking. What are the symptoms of ADHD? Consult your child's doctor If you