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508-4.011, P less then 0.001) or PLR (HR =2.086, 95% CI 1.279-3.402, P=0.003). Serum NSE also had a significant effect on patient survival (HR =2.651, 95% CI 1.358-5.178, P=0.004). The effects of peripheral blood lymphocytes (P=0.001), neutrophils (P=0.023) and platelets (P=0.051) on patient survival were compared by log-rank test. In multivariate survival analysis, NLR (P less then 0.001) and T category were vital for the prognoses of LCNEC patients. Conclusions The inflammatory or immunological markers, NLR and PLR in blood, w