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Adverse events were consistent with those in the overall population. Rates of grade 3/4 adverse events associated with hepatic decompensation were generally low and were more common among patients in the ALBI grade 2 subgroup. These results provide initial support of cabozantinib in patients with advanced HCC irrespective of ALBI grade 1 or 2. ClinicalTrials.gov number, NCT01908426. ClinicalTrials.gov number, NCT01908426.Heart failure (HF) is an important health problem worldwide whose stages have traditionally been classified from A to D. In a