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nesis of bone-marrow cells under oxidative stress. Trial registration Chinese Clinical Trial Registry, ID ChiCTR1800017581. Registered on 5 August 2018. URL http//www.chictr.org.cn.Background Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CN or vacuum-assisted biopsy (VA. A meta-analysis reported that 25.9% of invasive ductal carcinoma (IDC) cases are preoperatively diagnosed by CNB as DCIS. Risk facto