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Rheum palmatum L. (RpL) is a traditional Chinese medicine commonly used in clinical. However, there was no systematic research to elucidate the mechanisms of RpL acting on COPD. To explore the potential mechanisms against COPD based on network pharmacology. The active compounds of RpL were retrieved from TCMSP database, and their corresponding targets were obtained through TCMSP and STITCH databases. COPD-related targets were identified from the TTD, GeneCards and MalaCards database. Drug-disease genes were obtained through intersectio