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We demonstrated that ectopic DNMT3L interacted with PRC2 in MEFs. Our information also recommended that ectopic DNMT3L might guide PRC2 to redress deregulated chromatin regions in cells undergoing senescence. This research might lead to an epigenetic support strategy for beating aging-associated epimutation and senescence. Copyright © 2020 Yu, Hui, Kao, Liao, Yang, Hou, Hsieh, Chang, Tsai, Pinskaya, Yang, Chen, Morillon, Tsai and Lin.The harm of fine particulate matter (PM2.5) to general pub