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Thus, the induction of ICD in B16F10 cells by PDT occurs only at a specific range of AlPcNE concentrations. Different therapies have been used for dissecting cellulitis of the scalp (DCS) with poor results. Topical 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective for many inflammatory skin diseases. To evaluate the efficacy and safety of fire micro-needling plus 5% ALA-PDT on DCS. Forty-two male DCS patients were enrolled and treated by four sessions of fire micro-needling plus 5% ALA-PDT (occlusion time 3h, 100mW/cm fo