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Importance Despite recent advances in remedy for serious aortic device stenosis (AS), AS remains a life-threatening condition with no confirmed disease-modifying therapy. Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) are implicated into the pathobiology of like. The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab lowers circulating LDL-C concentrations by 50% to 60per cent and Lp(a) by 20per cent to 30per cent. Unbiased To determine whether evoloc