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Multivariate analysis showed that the number of events of hypoglycemia were higher in patients with previous severe hypoglycemia (IRR1.38; 95% CI 1.19-1.61; p0.001), high glycemic variability defined as Coefficient of Variation (CV%)36% (IRR 2.09; 95%CI 1.79-2.45; p0.001) and hypoglycemia unawareness. A protector effect was identified for adequate sensor calibration (IRR 0.77; 95%CI 0.66-0.90; p0.001), and the use of bolus wizard 60% (IRR 0.74; 95%CI 0.58-0.95; p0.017). In spite of using advanced SAPT, clinically signific
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