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Mean EI was significantly improved after the second treatment compared to baseline, which maintained until the study period. MI and TEWL showed a tendency toward improvement. There were no serious adverse events reported during the study. IPBRF led to rapid clinical improvement in facial erythema associated with rosacea and acne vulgaris and could be an effective and safe treatment option. There is a dearth of lesbian gay, bisexual, transgender, and queer (LGBTQ+) mental health research in Southeast Europe. Our study aimed to explore M