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However, the observed relationship was not statistically significant (2013 r = -0.066, 2014 r = -0.155, 2015 r = -0.051, P 0.05. CONCLUSION The results of mapping with GIS and statistical analysis with SPSS both indicated a non-significant inverse relationship between the water hardness and CVDs. However, lack of a significant relationship highlights the necessity of conducting similar studies involving larger sample sizes and wider areas of investigation to present a definitive and generalizable result. © 2019 Isfahan Cardiova