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The results demonstrate the crucial role of nanoformulation elasticity for brain-tumor targeting and will be useful for the design of future brain targeting drug delivery systems for the treatment of brain disease.Chronotype and cognitive ability are two human phenotypes with an uneven geographic distribution due to both selective migration and causal environmental effects. In our study, we aimed to examine the relationship between geographic variables, cognitive ability and chronotype. We used a large anonymized sample (n = 25,700, mostl