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Fourier transform infrared spectroscopy (FTIR) showed that functional groups of EPS and Synechocystis cells, including -NH, -OH, CO, and CC, interacted with As species. Together the results of this work demonstrate that EPS have significant impacts on cell surface properties, thereby affecting As accumulation and transformation in Synechocystis PCC6803. This work provides a basis for using EPS to remedy As pollution in aquatic environments. BACKGROUND The presence of plus disease is important in determining when to treat retinopathy of