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Resveratrol improves cell apoptosis and tissue damage induced by high glucose, but the specific mechanism is unknown. This is a basic research. We performed cell transfection, real-time fluorescence quantitative PCR (qPCR), flow cytometry, immunofluorescence, western blot, enzyme linked immunosorbent assay (ELISA) and cell viability assay to analyze cell viability, cell cycle, cellular oxidative stress, intracellular inflammatory factors and autophagy activities . Meanwhile, dual luciferase reporter assay was conducted to explore the influ