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Gastroenterological research has traditionally been based on experimental approaches rather than mathematical modeling. However, the various patterns of the gastrointestinal (GI) tract functions are generated by the integrated function of multiple tissues and cell types. Hence, a thorough study of the gut requires understanding of the interaction between cells, tissues and GI organs in health and diseases. A unique way of coping with this explosion in complexity is mathematical modeling. Novel modeling analysis together with development of