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© 2019 John Wiley Sons, Ltd.Scarless skin regeneration with useful structure continues to be a challenge for full-thickness wounds . Here, mesenchymal stem cell (MSC)-laden hydrogels tend to be created for scarless wound healing with hair follicles. Microgels consists of aligned silk nanofibers are acclimatized to load MSCs to modulate the paracrine. MSC-laden microgels are dispersed into injectable silk nanofiber hydrogels, creating composites biomaterials containing the cells. Th