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Most Effective ADHD Medication For Adults Most adults find that medication can help ease their ADHD symptoms, so that they can focus, feel calm and have better relationships. Other treatment options, such as psychotherapy, can also be assisted with medication. Adults suffering from ADHD are more likely to benefit from stimulants. These include methylphenidate compounds and amphetamines. Adults may take short-acting medicines often throughout the day or long-acting ones that begin slow and last for between 3 and 6 hours. Stimulants The most efficient