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The synthetic impurity obtained was in pure form to provide a certified reference standard or working standard to stakeholders with defined potency. CONCLUSION The present research describes a novel technique for the synthesis of pharmaceutical impurity which can help in checking/controlling the quality of the CLRM in the international markets. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Circulating bladder tumor cells provide significant information for cancer diagnosis, tumor staging and personal