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Ursolic acid (UA) is an all natural triterpenoid which possesses anti-cancer task. However, small is known in connection with task and molecular apparatus of UA in cholangiocarcinoma (CCA). Thus, we investigated the consequences of UA on development inhibition and apoptosis induction through biomolecular changes in KKU-213 and KKU-055 CCA cell lines. The anti-proliferative effectation of UA against CCA cells had been assessed using SRB assay. Alterations in biomolecules had been a