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To evaluate the safety of the combination of methadone and an atypical antipsychotic in PICU patients. This was a retrospective observational cohort pilot study in a single-center PICU in an academic children's hospital. Children 1 month to 18 years of age were included if they received methadone, were then initiated on an atypical antipsychotic (i.e., quetiapine or risperidone), and had EKG monitoring before and after medication initiation. Prolongation of the corrected QT (QTc) interval occurred in 5 of the 34 included patients when a
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