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Generating considerable amounts of industrial waste requires rethinking chemistry for circularity in a broader picture. We discuss the study by Wołos et al. (2022) showing that the critical application of artificial intelligence on chemical reactivity can help us trace an unprecedented number of syntheses to novel responsible uses of waste.Innovations in soft materials bridge electronic conduction in conventional electronics and ionic conduction in biology. In a recent issue of Science, Dobashi et al. describe a hydroge