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The present study summarizes the current status of, and elaborates on several recent developments for, SSD methods, specifically, model averaging, multimodality, and software development. We also consider future directions with respect to the use of SSDs, with the ultimate aim of helping to facilitate greater international collaboration and, potentially, greater harmonization of SSD methods. Environ Toxicol Chem 2021;40293-308. © 2020 SETAC.Aquagenic pruritus is a rare debilitating condition, which can be idiopathic, iatrogenic, or asso
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