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Eligible studies will be critically appraised for methodological quality. Prevalence estimates will be statistically pooled in a meta-analysis after heterogeneity interpretation; data not appropriate for pooling will be reported in a narrative review. Finally, risk of publication bias will be studied via funnel plot analysis and the Egger test. PROSPERO (CRD42019143054). PROSPERO (CRD42019143054). The objective of this review is to identify and synthesize the risk factors for hyperglycemia or hypoglycemia in adults with pharmacological