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Compared with Galligas, Ga-68 EDTA aerosols were more concentrated in the central region in all groups except for the healthy nonsmokers. Ventilation inhomogeneity was more evident when using Ga-68 EDTA aerosols, especially in patients with COPD and asthma patients. In the healthy smokers, the central region accumulated more Ga-68 EDTA at 30minutes after inhalation than immediately after inhalation. Ga-68 EDTA cleared faster in lungs than Galligas. Both Galligas and Ga-68 EDTA aerosols can be used for PET/CT lung ventilation scan. However,