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These suggested that different functional bacteria differed in their responses to Fe(III) stress. Furthermore, long-term Fe(III) exposure significantly up-regulated the abundances of genes associated with nitrogen metabolism and Fe(III) reduction. Overall, the obtained findings are expected to advances our understanding of the responses of anammox process to elevated Fe(III) stress.Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles have emerged as a promising platform for drug delivery and controlled release. Considering most ZIF-8